{"product_id":"uva-ursi-500mg-60-capsules-supreme-nutrition-products","title":"Uva Ursi 500mg - 60 Capsules | Supreme Nutrition Products","description":"\u003cp data-mce-fragment=\"1\"\u003eUva ursi (Arctostaphylos uva-ursi), or bearberry, is a flowering alpine herb in the blueberry family with a long history of use in European and western herbalism. The leaves are the part used for medicine and have been traditionally used for urinary tract infections. The dried leaves historically have been used boiled or steeped in water to form a tea, however, powdered encapsulated products have been safely used since the 1970’s\u003csup data-mce-fragment=\"1\"\u003e[1]\u003c\/sup\u003e.\u003c\/p\u003e\u003cp data-mce-fragment=\"1\"\u003eThe first documented use of Uva ursi in literature appears in the 13\u003csup data-mce-fragment=\"1\"\u003eth\u003c\/sup\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003ecentury in a Welsh medical text. The herbal remedy was more used in northern areas of Europe before coming into more widespread used in central Europe. By the middle of the 18\u003csup data-mce-fragment=\"1\"\u003eth\u003c\/sup\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003ecentury, Uva ursi was widely used in Europe and by the beginning of the 19\u003csup data-mce-fragment=\"1\"\u003eth\u003c\/sup\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003ecentury it was considered an “official medicine”. Historical uses include treatment of kidney stones, diabetes, gonorrhea, edema, urinary tract infections, and as a diuretic.\u003c\/p\u003e\u003cp data-mce-fragment=\"1\"\u003eResearch has shown that Uva ursi has strong direct antimicrobial activity\u003csup data-mce-fragment=\"1\"\u003e[2]\u003c\/sup\u003e.  In regard to its use in treating urinary tract infections, Uva ursi has been shown to prevent UTIs even in high-risk populations\u003csup data-mce-fragment=\"1\"\u003e[3][4]\u003c\/sup\u003e. Uva ursi leaves have been shown to be inhibitory against Staphylococcus aureus\u003csup data-mce-fragment=\"1\"\u003e[5]\u003c\/sup\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eand can exert a pro-oxidative effect on E. coli and also chelate iron, which causes the bacteria to be more susceptible to destruction\u003csup data-mce-fragment=\"1\"\u003e[6]\u003c\/sup\u003e. Uva ursi leaves have been shown to inhibit growth of Neisseria gonorrheae, the causative agent of the STI gonorrhea\u003csup data-mce-fragment=\"1\"\u003e[7]\u003c\/sup\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eand has exhibited antimicrobial activity towards a variety of organisms including Mycobacterium smegmatis, Shigella sonnei and Shigella flexeneri\u003csup data-mce-fragment=\"1\"\u003e[8]\u003c\/sup\u003e. Extracts or Uva ursi have been shown to be active against Acinetobacter baumanii\u003csup data-mce-fragment=\"1\"\u003e[9]\u003c\/sup\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eand H. pylori\u003csup data-mce-fragment=\"1\"\u003e[10]\u003c\/sup\u003e. Uva Ursi inhibited the growth in vitro of Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Serratia marcescens and Staphylococcus aureus\u003csup data-mce-fragment=\"1\"\u003e[11]\u003c\/sup\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eKlebsiella pneumoniae, Candida albicans and Mycobacterium phlei\u003csup data-mce-fragment=\"1\"\u003e[12]\u003c\/sup\u003e.\u003c\/p\u003e\u003cp data-mce-fragment=\"1\"\u003eUva ursi was tested for bioactivity analyses against two strains of Chromobacterium violaceum. Chromobacterium violaceum is well known for their resistance to many antibiotics. Uva ursi showed direct antimicrobial activity, non-specific and specific pro quorum sensing (QS) activities and anti-QS activity. Extracts of Uva-uris exhibited strong inhibition in these bacterial strains\u003csup data-mce-fragment=\"1\"\u003e[13]\u003c\/sup\u003e.\u003c\/p\u003e\u003cp data-mce-fragment=\"1\"\u003eUva ursi has been shown to have antiviral activity in vitro against Herpes simplex virus type 2, influenza virus A2 and vaccinia virus\u003csup data-mce-fragment=\"1\"\u003e[14]\u003c\/sup\u003e.\u003c\/p\u003e\u003cp data-mce-fragment=\"1\"\u003eRegarding its traditional use for kidney stones, research has shown Uva ursi to have an inhibitory effect on calcium oxalate kidney stones by 95%\u003csup data-mce-fragment=\"1\"\u003e[1]\u003c\/sup\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eClinical testing has shown uva ursi to be helpful to help clear the body of oxalates which can be implicated in various pain syndromes and other issues.\u003c\/p\u003e\u003cp data-mce-fragment=\"1\"\u003eThe main active chemical constituent of Uva Ursi is Arbutin which makes up 7-17% of the dry weight of the leaves. Methyl arbutin makes up at least 4%. Arbutin readily hydrolyses in the body to form hydroquinone which has potent antimicrobial properties\u003csup data-mce-fragment=\"1\"\u003e[2]\u003c\/sup\u003e. Aside from this, arbutin has been shown to have antioxidant and anti-inflammatory properties inhibiting TNF-alpha and Il-6\u003csup data-mce-fragment=\"1\"\u003e[3]\u003c\/sup\u003e. Topically, both arbutin and hydroquinone have been used to lighten the skin\u003csup data-mce-fragment=\"1\"\u003e[4][5]\u003c\/sup\u003e. Other notable constituents of Uva ursi include tannins (10-20%), methylhydroquinone, anthocyanadins, salicylic acid, quercetin derivatives, and allantoin\u003csup data-mce-fragment=\"1\"\u003e[6]\u003c\/sup\u003e.\u003c\/p\u003e\u003cp data-mce-fragment=\"1\"\u003eSafety: Uva ursi extracts have been shown to be very safe. In animal models fed 25 mg\/kg\/day crude uva ursi extract for 90 days, no pathologies were observed\u003csup data-mce-fragment=\"1\"\u003e[7]\u003c\/sup\u003e. High dose and long term use is discouraged due to some of its strong components. We recommend not taking more than one bottle without taking a break of at least 1-2 months.\u003c\/p\u003e\u003cp data-mce-fragment=\"1\"\u003eReferences available on request.\u003c\/p\u003e","brand":"Supreme Nutrition Products","offers":[{"title":"Default Title","offer_id":45689035325691,"sku":"SN_048","price":30.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0693\/1578\/9051\/files\/SN_048-Uva-Ursi_c59223f3-ac81-4a76-ac15-a411fae09438.png?v=1766318005","url":"https:\/\/shop.amritaplus.com\/products\/uva-ursi-500mg-60-capsules-supreme-nutrition-products","provider":"ANGL Dev Store","version":"1.0","type":"link"}